Oral administration of bitter gourd (Momordica Charantia) extract prevent dyslipidemia on male wistar rats (rattus norvegicus) fed with high-fat diet

  • Hendrik Danico Master Program in Biomedical Sciences, Anti-Aging Medicine Concentration; Faculty of Medicine, Universitas Udayana, Denpasar, Bali
  • Wimpie Pangkahila Department of Andrology and Sexology, Faculty of Medicine, Universitas Udayana, Denpasar, Bali
  • I Gusti Made Aman Department of Pharmacology, Faculty of Medicine, Universitas Udayana, Denpasar, Bali

Abstract

Introduction: Dyslipidemia is one of the most prevalent health conditions and often leads to development of many chronic diseases such as coronary artery disease, heart failure, and stroke. This study was conducted to investigate the effects of bitter gourd (Momordica Charantia) extract on lipid profiles in male wistar rats fed with high-fat diet.


Methods: This study was an experimental research using randomized post-test only control group design. The subjects were 36 male Wistar rats (Rattus norvegicus) randomly divided into 2 groups. The first group was the control group (P0) and fed with placebo while the treatment group (P1) received bitter gourd (Momordica Charantia) ethanol extract at 1g/kg body weight/day. Both groups were fed with high fat diet. The experiment was lasted for 35 days and lipid profiles were measured at the end of the experiment.


Results: Statistical analysis results revealed the mean of total cholesterol, triglyceride, and low-density lipoprotein (LDL) in the treatment group were significantly lower than control group while high-density lipoprotein (HDL) was significantly higher in the treatment group (p<0.05).


Conclusion: This study concluded that bitter gourd extract significantly prevent dyslipidemia on male Wistar rats fed with high-fat diet.

Author Biographies

Hendrik Danico, Master Program in Biomedical Sciences, Anti-Aging Medicine Concentration; Faculty of Medicine, Universitas Udayana, Denpasar, Bali

Master Program in Biomedical Sciences, Anti-Aging Medicine Concentration; Faculty of Medicine, Universitas Udayana, Denpasar, Bali

Wimpie Pangkahila, Department of Andrology and Sexology, Faculty of Medicine, Universitas Udayana, Denpasar, Bali

Department of Andrology and Sexology, Faculty of Medicine, Universitas Udayana, Denpasar, Bali

I Gusti Made Aman, Department of Pharmacology, Faculty of Medicine, Universitas Udayana, Denpasar, Bali

Department of Pharmacology, Faculty of Medicine, Universitas Udayana, Denpasar, Bali

Published
2020-06-01
How to Cite
DANICO, Hendrik; PANGKAHILA, Wimpie; AMAN, I Gusti Made. Oral administration of bitter gourd (Momordica Charantia) extract prevent dyslipidemia on male wistar rats (rattus norvegicus) fed with high-fat diet. IJAAM (Indonesian Journal of Anti-Aging Medicine), [S.l.], v. 4, n. 1, p. 20-23, june 2020. ISSN 2615-5079. Available at: <https://ijaam-unud.org/ojs/index.php/ijaam/article/view/49>. Date accessed: 20 jan. 2021. doi: https://doi.org/10.36675/ijaam.v4i1.49.