Oral administration of clabet (Trigonella foenum graecum) seeds ethanol extracts improved testosteron level in old-male wistar (Rattus norvegicus) mice

  • Bissi Herliane Master Program in Biomedical Sciences Study Program Specificity of Anti-Aging Postgraduate Program Udayana University Denpasar
  • Wimpie Pangkahila Department of Andrology and Sexology, Faculty of Medicine, Udayana University
  • IGM Aman Department of Phrmacology Faculty of Medicine, Udayana University

Abstract

Introduction: Aging can cause decreased testosterone levels in men which is known as andropause. Some herbs are known to increase the levels Testosterone. One of them is Klabet seed that contain phyto-testosterone. The purpose of this study was to prove that the administration of ethanol extract of Klabet seeds increased testosterone levels in old male Wistar rats.
Methods: A pretest-posttest control group design study was conducted using 20 male white wistar rats that were divided into 2 (two) groups: control group that received 2 cc of distilled water and treatment group that received 2 cc ethanol extract of Klabet seeds 250mg/250gBB rats/day by sonde for 14 days. The testosterone level was measured on day 1 and 15.
Results: The analysis showed that there was no significant difference in the pre-test and post-test testosterone level P0 (Pre-test:16.4±0.553 ng/ml; posttest: 15.9±1.51ng/ml) while increased level of testosterone could be observed in treatment group (P1) (pre-test: 16.6±0.476ng/ml; post-test: 19.4±0.828ng/ml. Comparative analysis between post-test results (P0 vs P1) showed that the difference was statistically significant (p <0.001).
Conclusion: Oral administration of Klabet seeds ethanol extract can significantly increase testosterone level in old male wistar mice.

Author Biographies

Wimpie Pangkahila, Department of Andrology and Sexology, Faculty of Medicine, Udayana University

Department of Andrology and Sexology, Faculty of Medicine, Udayana University

IGM Aman, Department of Phrmacology Faculty of Medicine, Udayana University

Department of Phrmacology Faculty of Medicine, Udayana University

Published
2018-12-31
How to Cite
HERLIANE, Bissi; PANGKAHILA, Wimpie; AMAN, IGM. Oral administration of clabet (Trigonella foenum graecum) seeds ethanol extracts improved testosteron level in old-male wistar (Rattus norvegicus) mice. IJAAM (Indonesian Journal of Anti-Aging Medicine), [S.l.], v. 2, n. 2, p. 40-42, dec. 2018. ISSN 2615-5079. Available at: <https://ijaam-unud.org/ojs/index.php/ijaam/article/view/69>. Date accessed: 08 apr. 2020.