Administration of oral tranexamic acid is equally effective with intradermal injections in reducing the amount of melanin in female marmots (Cavia porcellus) exposed to ultraviolet-b

  • Ni Luh Putri Astini Master Program in Biomedical Sciences Study Program Specificity of Anti-Aging Postgraduate Program Udayana University Denpasar
  • Wimpie Pangkahila Department of Dermatology and Venerology Faculty of Medicine, Udayana University
  • AAGP Wiraguna Department of Dermatology and Venerology Faculty of Medicine, Udayana University

Abstract

Introduction: Oral studies of tranexamic acid significantly reduce the MASI (Melasma Area and Severity Index) value but have not evaluated a decrease in the amount of melanin. The purpose of this study is to prove that oral tranexamic acid can reduce the amount of melanin and have the same effectiveness as intradermal injections in female guinea pigs exposed to ultraviolet B.
Method: A posttest only control group design study was conducted using 32 female mice, aged 6-8 weeks, weight 250-280 grams, which were randomly divided into 2 groups. Group 1 was given an intradermal injection of tranexamic acid 5 mg/ml, 0.5 ml/cm and exposure to UVB. Group 2 was given oral treatment of tranexamic acid 250 mg twice a day and exposure to UVB. The treatment was given for 4 weeks. Total UVB exposure was 390mj/sec. The study was conducted in the animal laboratory of the Udayana medical faculty.
Results: The statistic result showed that the data were normally distributed and homogenous. The comparative test with the independent sample t-test indicated that there was no significant difference between intradermal injections with oral tranexamic acid administration in reducing the amount of melanin in female guinea pigs exposed to UVB with p> 0.05.
Conclusion: oral tranexamic acid significantly reduced the amount of melanin and had the same effectiveness as intradermal injections in reducing the amount of melanin in female guinea pigs exposed to UVB.

Author Biographies

Wimpie Pangkahila, Department of Dermatology and Venerology Faculty of Medicine, Udayana University

Department of Dermatology and Venerology Faculty of Medicine, Udayana University

AAGP Wiraguna, Department of Dermatology and Venerology Faculty of Medicine, Udayana University

Department of Dermatology and Venerology Faculty of Medicine, Udayana University

Published
2018-12-31
How to Cite
ASTINI, Ni Luh Putri; PANGKAHILA, Wimpie; WIRAGUNA, AAGP. Administration of oral tranexamic acid is equally effective with intradermal injections in reducing the amount of melanin in female marmots (Cavia porcellus) exposed to ultraviolet-b. IJAAM (Indonesian Journal of Anti-Aging Medicine), [S.l.], v. 2, n. 2, p. 43-46, dec. 2018. ISSN 2615-5079. Available at: <https://ijaam-unud.org/ojs/index.php/ijaam/article/view/70>. Date accessed: 23 feb. 2020.