Awarding of green coffee bean (Coffea arabica) extract improved lipid profile in dyslypidemic male wistar rats (Rattus norvegicus)

  • Fibriany Chandra Master Program in Biomedical Sciences Study Program Specificity of Anti-Aging Postgraduate Program Universitas Udayana Denpasar
  • I Wayan Weta Public Health/Clinical Nutrition Department, Faculty of Medicine, Universitas Udayana, Denpasar, Bali
  • Ni Nyoman Ayu Dewi Biochemistry Department of Andrology and Sexology, Faculty of Medicine, Universitas Udayana, Denpasar, Bali

Abstract

Introduction: Dyslipidemia is a lipid metabolic disorder characterized by increased or decreased lipid fraction in plasma. The active compounds of chlorogenic acid in coffee can increases the body’s metabolism, increases fatty acid oxidation, decreases triglyceride levels in the liver, and inhibit the action of the enzyme amylase and lipase pancreas in the intestinal. This study aimed to prove the effectiveness of green coffee bean extract in improving serum lipid profile levels in dyslipidemic male Wistar rats.


Methods: The research design was experimental pre-post test control group using 14 male Wistar rats. The control group was given placebo (2 cc aquades), while the second group was treated with ethanol extract of green beans dose 200 mg/kg dissolved in 2 cc aquades given sonde with treatment time of 14 days. On the first and fifteenth days, blood sampling is done to check the lipid profile level.


Results: The results showed that the mean total cholesterol level of the control group was 137.86 ± 10.12 mg/dL while the total cholesterol level in the treatment group was 137.86 ± 10.12 mg/dL. The mean of triglyceride level, LDL level, and HDL level control group was 100.86 ± 8.98 mg/dL, 97.57 ± 4.65 mg/dL, and 51.57 ± 4.96 mg/dL while triglyceride level, LDL level, and HDL level in treatment group was 76.86 ± 4.94 mg/dL, 82.86 ± 5.21 mg/dL and 66.43 ± 8.84 mg/dL.


Conclusion: Arabica green coffee bean (Coffea arabica) extract improves the lipid profile of dyslipidemic male Wistar rats (Rattus norvegicus).

Author Biographies

Fibriany Chandra, Master Program in Biomedical Sciences Study Program Specificity of Anti-Aging Postgraduate Program Universitas Udayana Denpasar

Master Program in Biomedical Sciences Study Program Specificity of Anti-Aging Postgraduate Program Universitas Udayana Denpasar

I Wayan Weta, Public Health/Clinical Nutrition Department, Faculty of Medicine, Universitas Udayana, Denpasar, Bali

Public Health/Clinical Nutrition Department, Faculty of Medicine, Universitas Udayana, Denpasar, Bali

Ni Nyoman Ayu Dewi, Biochemistry Department of Andrology and Sexology, Faculty of Medicine, Universitas Udayana, Denpasar, Bali

Biochemistry Department of Andrology and Sexology, Faculty of Medicine, Universitas Udayana, Denpasar, Bali

Published
2021-12-01
How to Cite
CHANDRA, Fibriany; WETA, I Wayan; DEWI, Ni Nyoman Ayu. Awarding of green coffee bean (Coffea arabica) extract improved lipid profile in dyslypidemic male wistar rats (Rattus norvegicus). IJAAM (Indonesian Journal of Anti-Aging Medicine), [S.l.], v. 5, n. 2, p. 98-102, dec. 2021. ISSN 2615-5079. Available at: <https://ijaam-unud.org/ojs/index.php/ijaam/article/view/83>. Date accessed: 17 may 2022. doi: https://doi.org/10.36675/ijaam.v5i2.83.