The 20% of petai seed (Parkia speciosa) extract cream in inhibited the increase of melanin counts in the skin of guinea pigs (Cavia porcellus) exposed to ultraviolet B

  • Nining Triyana Darise Master Program in Biomedical Sciences Study Program Specificity of Anti-Aging Postgraduate Program Universitas Udayana Denpasar
  • Wimpie Pangkahila Department of Andrology and Sexology, Faculty of Medicine, Universitas Udayana
  • AAGP Wiraguna Department of Dermatology and Venerology, Faculty of Medicine, Universitas Udayana

Abstract

Introduction: The exposure to UV  may cause skin disorders, including hyperpigmentation. Petai seeds are categorized as traditional medicinal plants that have anti-inflammatory and antioxidant effects, such as flavonoids, tannins, phenols and vitamin C which have the function of inhibiting the tyrosinase enzyme and the synthesis of melanin. The aim of this research was to prove that a 20% of Petai seed (Parkia speciosa) extract cream could prevent the increase of melanin counts in the skin of Guinea Pigs (Cavia porcellus) exposed to UV-B.


Method: This research employed an experimental study through a randomized post-test only control group design that used 36 male guinea pigs (Cavia porcellus) that divided into 2 (two) groups each of which were 18 guinea pigs. In order to find out the mass, melanin stained with Masson-Fontana, the melanin count was showed in percent. The results of this research were then analyzed and used descriptive analysis, data normality, data homogeneity, and comparability tests.


Results: The results indicated that the mean was 20.543 ± 3.344%, whereas, in the treatment group that smeared by 20% of petai seed extract cream, the mean value was 1.533 ± 0.518% (p <0.001). This indicated that the treatment group had a smaller melanin count than the control group.


Conclusion: Based on the results of this research, it can be concluded that 20% of petai seed extract cream inhibited the increase of melanin counts in guinea pigs’ skin exposed to UV-B.

Author Biographies

Nining Triyana Darise, Master Program in Biomedical Sciences Study Program Specificity of Anti-Aging Postgraduate Program Universitas Udayana Denpasar

Master Program in Biomedical Sciences Study Program Specificity of Anti-Aging Postgraduate Program Universitas Udayana Denpasar

Wimpie Pangkahila, Department of Andrology and Sexology, Faculty of Medicine, Universitas Udayana

Department of Andrology and Sexology, Faculty of Medicine, Universitas Udayana

AAGP Wiraguna, Department of Dermatology and Venerology, Faculty of Medicine, Universitas Udayana

Department of Dermatology and Venerology, Faculty of Medicine, Universitas Udayana

Published
2021-12-01
How to Cite
DARISE, Nining Triyana; PANGKAHILA, Wimpie; WIRAGUNA, AAGP. The 20% of petai seed (Parkia speciosa) extract cream in inhibited the increase of melanin counts in the skin of guinea pigs (Cavia porcellus) exposed to ultraviolet B. IJAAM (Indonesian Journal of Anti-Aging Medicine), [S.l.], v. 5, n. 2, p. 75-77, dec. 2021. ISSN 2615-5079. Available at: <https://ijaam-unud.org/ojs/index.php/ijaam/article/view/87>. Date accessed: 17 may 2022. doi: https://doi.org/10.36675/ijaam.v5i2.87.