Ethanol extract of red fruit (Pandanus conoideus lam.) improved lipid profile of dyslipidemic-male wistar rats (Rattus norvegicus)

  • Sriwiyanti Sriwiyanti Master Program in Biomedical Sciences Study Program Specificity of Anti-Aging Postgraduate Program Universitas Udayana Denpasar
  • I Gusti Made Aman Department of Pharmacology Medical Faculty Universitas Udayana Denpasar
  • Gde Ngurah Indraguna Pinatih Department of Clinical Nutrition, Faculty of Medicine, Universitas Udayana Denpasar

Abstract

Introduction: Dyslipidemia is one of aging- related disease associated with unhealthy food such as high calories and fat. Pandanus Conoideus Lam. with high antioxidant capacity might ameliorates dyslipidemia phenotypes. This study aimed to prove that ethanol extract of red fruit improves lipid profiles of dyslipidemic-rats (Rattus norvegicus).


Methods: This was an experimental study with a pretest-posttest control group design, using 14 wistar rats males. Rats were then divided into 2 groups (n= 7). The first group was treated with aquabidestilata 1 mL for 30 days (P0). The second group was treated with extract of red fruit ethanol of 168 mg/200 gr BW for 30 days (P1).


Results: The control group (P0) treated with aquabidestilata, total cholesterol levels increased into 221.48 ± 3.64 mg/dl (p <0.05), triglyceride levels elevated into 132.92±3.01 mg/dl (p <0.05), HDL levels depleted into 22.83 ± 2.26 mg/dl (p <0.05), and LDL levels was increased from 76.77 ± 3.33 mg / dl to 78.63 ± 2.84 mg / dl (p <0.05). In contrast, the red fruit ethanol extract in treatment group (P1) experienced decrease on total cholesterol level into 118.41 ± 2.15 mg/dl (p <0.05), triglyceride levels into 91.81 ± 2.71 mg/dl (p <0.05), and LDL levels into 45.85 ± 2.59 mg/dl (p <0.05), and elevation on HDL levels from 25.77 ± 1.36 mg/dl to 55.76 ± 2.35 mg/dl (p <0.05).


Conclusion: This study indicated that administration of ethanol extract of red fruit (Pandanus conoideus lam.) improved lipid profiles of dyslipidemic-rats (Rattus norvegicus).

Author Biographies

Sriwiyanti Sriwiyanti, Master Program in Biomedical Sciences Study Program Specificity of Anti-Aging Postgraduate Program Universitas Udayana Denpasar

Master Program in Biomedical Sciences Study Program Specificity of Anti-Aging Postgraduate Program Universitas Udayana Denpasar

I Gusti Made Aman, Department of Pharmacology Medical Faculty Universitas Udayana Denpasar

Department of Pharmacology Medical Faculty Universitas Udayana Denpasar

Gde Ngurah Indraguna Pinatih, Department of Clinical Nutrition, Faculty of Medicine, Universitas Udayana Denpasar

Department of Clinical Nutrition, Faculty of Medicine, Universitas Udayana Denpasar

Published
2021-12-01
How to Cite
SRIWIYANTI, Sriwiyanti; AMAN, I Gusti Made; PINATIH, Gde Ngurah Indraguna. Ethanol extract of red fruit (Pandanus conoideus lam.) improved lipid profile of dyslipidemic-male wistar rats (Rattus norvegicus). IJAAM (Indonesian Journal of Anti-Aging Medicine), [S.l.], v. 5, n. 2, p. 78-80, dec. 2021. ISSN 2615-5079. Available at: <https://ijaam-unud.org/ojs/index.php/ijaam/article/view/88>. Date accessed: 17 may 2022. doi: https://doi.org/10.36675/ijaam.v5i2.88.